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Sleep Apnea, ObstructiveSleepDrugPhase 2

What this study is

Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating moderate-substantial interrater and test-retest reliability. This research has also compared DISE findings to those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not responded to previous sleep apnea surgery. These papers have been published and available through PubMed. Additional research is ongoing, with examination of DISE findings, comparison to other evaluation techniques, and the association between DISE findings and surgical outcomes.

What's being tested

  • Propofol sedation

    Intervention · DRUG

    Patients receive an intravenous propofol infusion titrated to reach a target level of sedation, sleep with arousability to verbal stimuli.

Study details

Sponsor
University of California, Los Angeles
Conditions
Sleep Apnea, Obstructive
Enrolling
800 people
Starts
2004-02
Est. completion
2035-06
Design
Open-label, single group, Phase 2
Record
View on ClinicalTrials.gov ↗