What this study is
Prospective, interventional cohort study of drug-induced sleep endoscopy (DISE) to evaluate the upper airway in a cohort of obstructive sleep apnea (OSA) surgical patients. This study has investigated the reliability of this technique, demonstrating moderate-substantial interrater and test-retest reliability. This research has also compared DISE findings to those of the lateral cephalogram X-ray and examined DISE findings in individuals who have not responded to previous sleep apnea surgery. These papers have been published and available through PubMed. Additional research is ongoing, with examination of DISE findings, comparison to other evaluation techniques, and the association between DISE findings and surgical outcomes.
What's being tested
- Propofol sedation
Intervention · DRUG
Patients receive an intravenous propofol infusion titrated to reach a target level of sedation, sleep with arousability to verbal stimuli.
Study details
- Sponsor
- University of California, Los Angeles
- Conditions
- Sleep Apnea, Obstructive
- Enrolling
- 800 people
- Starts
- 2004-02
- Est. completion
- 2035-06
- Design
- Open-label, single group, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Adult patients with OSA considering surgical treatment
You can't join if
- Minors
- Pregnant women
- Patients unable to provide informed consent in English themselves
- Prisoners
- Allergy to propofol, soybean oil, egg lecithin or glycerol
- Other contraindication to use of propofol (decision of anesthesiologist or otolaryngologist.)
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUCLA Santa Monica Medical Center
Santa Monica, California, United States
- Eric Kezirian, MD, MPH · Contact
- Eric Kezirian, MD, MPH · Principal investigator
Recruiting
Study team
Sponsor
University of California, Los Angeles
Study ID HS-13-00379
Principal investigator
Eric J Kezirian, MD, MPH
University of California, Los Angeles
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.