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Lung CancerGeneticsGeneticProcedure

What this study is

RATIONALE: Using samples of blood, urine, sputum, and lung tissue from patients at high risk of cancer for laboratory studies may help doctors learn more about changes that may occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is looking at molecular predictors of cancer in patients at high risk of lung cancer.

What's being tested

  • comparative genomic hybridization

    Intervention · GENETIC

  • gene expression microarray analysis

    Intervention · GENETIC

  • proteomic profiling analysis

    Intervention · GENETIC

  • biologic sample preservation procedure

    Intervention · OTHER

  • nasal brushing

    Intervention · PROCEDURE

    Using a brush, superficial cells are removed from the nose.

  • Blood draw

    Intervention · PROCEDURE

    Venous blood will be collected

  • Urine collection

    Intervention · PROCEDURE

    Subjects will be asked to provide a urine specimen.

  • sputum sample

    Intervention · PROCEDURE

    Prior to their bronchoscopy, subjects will be asked for a sputum specimen. This is a collection of mucous that you cough up.

  • fluorescence bronchoscopy with airway biopsy

    Intervention · PROCEDURE

    A flexible tube attached to a fluorescent light source will be inserted into the subject's mouth or nose to reach the airway. Samples of the lining of the airway will be taken, as well as bronchial secretions and epithelial cell from brushings of the lining of the airway.

  • fine needle aspiration of the lung

    Intervention · PROCEDURE

    A small needle is inserted into the lung to collect tissue. This procedure will only be performed if the patient's physician orders it.

  • thoracentesis

    Intervention · PROCEDURE

    A small needle is inserted into the patient's lung cavity and a small amount of fluid is collected. This procedure will only be performed if the patient's physician orders it.

All of comparative genomic hybridization, gene expression microarray analysis, proteomic profiling analysis, biologic sample preservation procedure

Collection of sputum, blood, urine, and a small amount of lung tissue.

Study details

Official title
Molecular Predictors of Lung Cancer Behavior
Sponsor
Vanderbilt-Ingram Cancer Center
Conditions
Lung Cancer
Enrolling
4,000 people
Starts
2003-12
Est. completion
2027-01-31
Record
View on ClinicalTrials.gov ↗