What this study is
Magnetic resonance imaging (MRI), as a non-invasive and non-contrast enhanced technique, has the potential to improve patient health care and management. The overall objective of proposed project is to:
1. develop, customize, and optimize anatomic and functional MRI methods, 2. explore the use of MRI methods to study CKD and evaluate post-transplant kidneys, and 3. investigate the potential of MRI in the diagnosis, prognosis, and monitoring of the progression of renal dysfunction.
In addition to direct studies of the kidney, brain MRI studies will also be performed to identify the cerebrovascular and cognitive effects of chronic renal function deficiency and medical treatment (e.g. hemodialysis and immunosuppression). The brain and kidneys have similar vascular bed, and both are susceptible to vascular injury, which provides the pathological basis for the widely recognized association of reduced renal function with prevalent cerebrovascular diseases (CVDs) and cognitive impairment (CI). The MRI methods in the brain will be applied to explore the origins for widely observed CVDs and prevalent cognitive impairment (CI) in kidney disease patients.
Study details
- Sponsor
- University of Minnesota
- Conditions
- Chronic Kidney Diseases · Kidney Transplantation · Dialysis · Cognition Disorders
- Enrolling
- 180 people
- Starts
- 2026-03-30
- Est. completion
- 2028-12-30
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 70 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- For Specific Aim 1: MRI Technical Development Studies
- 1. Healthy Volunteer
- English- speaking as primary language.
- Age 45 years and older
- Able to complete an approximately 90 minute cognitive testing battery.
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
- GFR < 90 ml/min/1.73m2
- Able to sign the informed consent, or allow a caregiver, relative, surrogate, or witness to sign the informed consent if participant is unable to do so.
- Age 45 years and older
You can't join if
- Ferromagnetic implants
- Any foreign metal objects in the body
- History of shrapnel or shot gun injury
- Cardiac pacemakers
- Defibrillator
- Neuronal stimulator
- Magnetic aneurysm clip
- Large tattoos on the abdomen or the brain and neck
- Hip replacement
- Too large to fit in the magnet (body mass index >= 40, approx.)
- Severe claustrophobia
- Women with pregnancy For Specific Aim 2: Pilot Studies with Patients Studies for CKD
- Acute psychiatric illness that would impede cognitive testing
- Active chemical dependence, such as alcohol, narcotics or other drugs
- Legally blind or unable to complete cognitive tests due to visual loss or deafness
- Dialysis dependent or renal transplant recipient at time of screening or baseline
- Chronic obstructive pulmonary disease
- Severe CI unable to complete the Modified Mini-Mental State Examination [3MSE] Studies for Renal Transplantation
- Not on dialysis due to allograft failure
- Chronic obstructive pulmonary disease
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openCenter for Magnetic Resonance Research
Minneapolis, Minnesota, United States
- Xiufeng Li, Ph.D. · Contact612-626-2001
- Xiufeng Li, Ph.D. · Principal investigator
Study team
Sponsor
University of Minnesota
Study ID 1410M54981
Principal investigator
Xiufeng Li, Ph.D.
Univesity of Minnesota
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.