What this study is
Objective: To evaluate the potential impact of molecular phenotyping of transbronchial biopsies in lung transplant recipients with allograft dysfunction, and the potential for developing a safer endobronchial mucosal biopsy format.
What's being tested
- Lung transplant biopsy bites.
Intervention · PROCEDURE
In the second phase of the study, two biopsy bites from the same patient will be collected to assess tissue sampling variability.
Study details
- Official title
- Multi-Centric Observational Study to Analyze the Diagnostic Molecular Features in the Clinical Setting of Lung Allograft Biopsies
- Sponsor
- University of Alberta
- Conditions
- Lung Transplant Rejection
- Enrolling
- 700 people
- Starts
- 2016-05
- Est. completion
- 2027-12
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- All lung transplant recipients undergoing a biopsy as determined by their surgeon or physician.
You can't join if
- Patients who declined participation or unable to give informed consent.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (11)
4 openSt. Joseph's Hospital and Medical Center 350 West Thomas Road, Floor 8HLT
Phoenix, Arizona, United States
- Chanti F Smith · Contact214-820-1771chanti.smith@dignityhealth.org
- Rajat Walia, MD · Principal investigator
RecruitingUniversity of Maryland School of Medicine
Baltimore, Maryland, United States
CompletedDivision of Pulmonary and Critical Care, Washington University School of Medicine
St Louis, Missouri, United States
CompletedUniversity of Texas at San Antonio
San Antonio, Texas, United States
Completed
7 sites outside the US
Alberta Transplant Applied Genomics Centre, University of Alberta
Edmonton, Alberta, Canada
- Konrad S Famulski, PhD · Contact1 780 492 1725konrad@ualberta.ca
- Philip F Halloran, MD, PhD · Principal investigator
RecruitingDepartment of Medicine, University of Alberta
Edmonton, Alberta, Canada
- Kieran Halloran, MD · Contact1 780 492 2691kieran.halloran@ualberta.ca
- Kieran Halloran, MD · Principal investigator
- Justin Weinkauf, MD · Sub-investigator
- Alim Hirji, MD · Sub-investigator
RecruitingCharles University/Hospital Motol
Prague, Czechia
- Jan Havlin, Dr · Contacthavlin.jan@gmail.com
- Jan Havlin, Dr · Principal investigator
RecruitingThe Alfred Hospital, Monash University
Melbourne, Australia
CompletedDepartment of Thoracic Surgery, Medical University of Vienna
Vienna, Austria
CompletedUniversity Health Network, Toronto General Hospital
Toronto, Ontario, Canada
CompletedThoracic Surgery Transplant Clinic
Szczecin, Poland
Completed
Study team
Sponsor
University of Alberta
Study ID ATAGC 03
Principal investigator
Philip F Halloran, MD, PhD
Faculty of Medicine and Dentistry, University of Alberta
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.