What this study is
Multi-center observational study to evaluate the histopathology and transcriptome of cutaneous lesions in patients with several different types of vasculitis.
Study details
- Sponsor
- Peter Merkel
- Conditions
- Cryoglobulinemic Vasculitis (CV) · Drug-induced Vasculitis · Eosinophilic Granulomatosis With Polyangiitis (EGPA) · IgA Vasculitis · Isolated Cutaneous Vasculitis · Granulomatosis With Polyangiitis (GPA) · Microscopic Polyangiitis (MPA) · Polyarteritis Nodosa (PAN) · Urticarial Vasculitis · Vasculitis
- Enrolling
- 50 people
- Starts
- 2017-01
- Est. completion
- 2028-12
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 5 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Have a cutaneous lesion (purpuric macules, palpable purpura, retiform purpura, nodules, ulcers, or urticarial) believed to be related to active vasculitis
- Have a suspected or confirmed diagnosis of:; Cryoglobulinemic vasculitis (CV); Drug-induced vasculitis; Eosinophilic granulomatosis with polyangiitis (EGPA); IgA vasculitis; Isolated cutaneous vasculitis; Granulomatosis with polyangiitis (GPA); Microscopic polyangiitis (MPA); Polyarteritis nodosa (PAN); Urticarial vasculitis
- Be willing and able to provide written informed consent (or assent for those under
You can't join if
- You are less than five years old
- Considered not to be a candidate for a biopsy or have a higher risk of developing an infection, bleeding, etc., from the biopsy, or a doctor believes that the risks for you participating in this study do not outweigh the potential benefit of learning information from your biopsy
- You have a neutrophil count (type of white blood cell) less than 1500/mm3, platelet count less than 50,000/mm3, or a hemoglobin less than 7 g/dL
- You have an uncontrolled disease that could prevent you from completing the study procedures
- You have an active infection at or near the potential biopsy site, have poor circulation, or have bony prominence or other structure that would increase your risk of complications if you participated in this study
- You are pregnant or nursing
- You are not able to provide informed consent
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
Study locations (10)
4 openUniversity of Pennsylvania
Philadelphia, Pennsylvania, United States
- Laura Cesar · ContactLaura.Cesar@Pennmedicine.upenn.edu
RecruitingUniversity of Virginia
Charlottesville, Virginia, United States
- Lauren Kuhns · Contactlrk9t@uvahealth.org
RecruitingUniversity of California, Los Angeles
Los Angeles, California, United States
CompletedBoston University School of Medicine
Boston, Massachusetts, United States
CompletedMayo Clinic
Rochester, Minnesota, United States
CompletedCleveland Clinic
Cleveland, Ohio, United States
CompletedOregon Health & Science University
Portland, Oregon, United States
CompletedUniversity of Utah
Salt Lake City, Utah, United States
Completed
2 sites outside the US
- Recruiting
University of Toronto Mount Sinai Hospital
Toronto, Ontario, Canada
- Nazrana Haq · ContactNazrana.Haq@sinaihealth.ca
Recruiting
Study team
Sponsor
Peter Merkel
Study ID VCRC5563
Principal investigator
Robert Micheletti, MD
University of Pennsylvania
Principal investigator
Peter Grayson, MD, MSc
The National Institute of Arthritis and Musculoskeletal and Skin Diseases
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.