What this study is
This study uses a meal-challenge protocol to assess if patients with anorexia nervosa show a differential metabolism in response to food in comparison to healthy controls. This study determines how heritable and biochemical factors influence food metabolism in anorexia nervosa in order to develop more effective treatment strategies.
What's being tested
- A breakfast sandwich
Intervention · OTHER
A meat-based breakfast sandwich
Study details
- Official title
- Solving EPHX2 and Polyunsaturated Fatty Acid Interactions in Anorexia Nervosa
- Sponsor
- University of California, San Diego
- Conditions
- Anorexia Nervosa
- Enrolling
- 300 people
- Starts
- 2016-11-10
- Est. completion
- 2027-12-31
- Design
- Open-label, non-randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 55 YearsSex FEMALEHealthy volunteers AcceptedYou may qualify if
- Ill AN subjects will meet current Diagnostic and Statistical Manual of Mental Disorders (DSM V) diagnosis of AN, body mass index (BMI) between 11 kg/m² and 17.5 kg/m², or BMI > 17.5 kg/m² with active eating disorder symptoms.
- Recovered AN must meet the following criteria at time of study entry: 1) Current or past DSM V diagnosis of AN; 2) BMI between 18.5 kg/m2 and 30 kg/m2; 3) Having maintained a BMI of >18.5 for at least one year.
- Control must be healthy adolescent or woman negative on our screen for AN, other Axis I psychiatric illnesses, and having maintained a BMI of between 18.5-30 kg/m² since the age of 18.
You can't join if
- Exclusion criteria for AN and control subjects include: Organic brain syndrome, schizophrenia and schizoaffective disorder, untreated thyroid disease, renal disease, hepatic disease, and the regular use of fish-oil containing supplements within the last three months of the study. All pregnant and lactating individuals will be excluded.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openContact for every open site
- Pei-an Betty Shih, MPM, PhD · Principal investigator
UC San Diego Altman Clinical and Translational Research Institute
La Jolla, California, United States
- P. Betty Shih, MPM, PhD · Contact858-534-0828eatingdisorderresearch@ucsd.edu
Recruiting
1 site outside the US
Program for Eating Disorders, Toronto General Hospital
Toronto, Ontario, Canada
- D. Blake Woodside · Contact416-340-4445pbshih@ucsd.edu
- D. Blake Woodside, MD FRCPC · Contact416-340-4445pbshih@ucsd.edu
- D. Blake Woodside, MD FRCPC · Principal investigator
Recruiting
Study team
Sponsor
University of California, San Diego
Study ID R01MH106781
Principal investigator
Pei-an (Betty) Shih, MPM, PhD
University of California, San Diego
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.