What this study is
The purpose of this study is to (1) quantify cardiovascular anatomy and physiology using magnetic resonance imaging under both resting and exercise conditions in patients who have congenital heart disease and in age-matched normal volunteers, (2) use computer models to reproduce and simulate blood flow in these patients, and then (3) to combine the imaging data and computer models to estimate values which cannot be directly measured and to predict physiological changes induced by exercise and medical or surgical therapies.
What's being tested
- Magnetic Resonance Imaging
Intervention · OTHER
All subjects will undergo or have already undergone Magnetic Resonance Imaging. Normal volunteers will be used for comparison with subjects. To minimize risk, normal volunteers will NOT undergo anesthesia, sedation or receive intravenous contrast during procedure.
Study details
- Official title
- MR Imaging and Computational Simulation of Cardiovascular Physiology Including Velocity, Pressure, and Wall Shear Stress
- Sponsor
- Stanford University
- Conditions
- Congenital Heart Disease · Pulmonary Hypertension
- Enrolling
- 75 people
- Starts
- 2008-02
- Est. completion
- 2029-02
- Record
- View on ClinicalTrials.gov ↗
Who can join
Sex ALLHealthy volunteers Not acceptedYou may qualify if
- Patients will have congenital heart disease or acquired cardiopulmonary disease.
- Normal volunteers will be willing to undergo MRI
You can't join if
- Patients unable to receive intravenous contrast material (this does not apply to normal volunteers)
- Subjects with arrhythmias which will prevent MRI cardiac gating
- Subjects with illnesses which make participation inappropriate. In addition, patients who would normally be excluded from an MRI study because of pacemaker implant, aneurysm clip, severe claustrophobia, or any other condition which, based on the Investigator's judgment, would preclude proximity to a strong magnetic field will be excluded from this study as well.
- NORMAL VOLUNTEERS may be excluded if they are not able to remain still during the exam or follow the instructions of the investigators.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
Study locations (1)
1 openLucile Packard Children's Hospital at Stanford
Palo Alto, California, United States
Study team
Sponsor
Stanford University
Study ID SQL 80004
Principal investigator
Jeffrey Feinstein, MD, MPH
Stanford University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.