Alcoholic Liver DiseaseHealthy volunteers
What this study is
In this study we plan to demonstrate that ethanol induces skeletal muscle autophagy to degrade MAA adducts.
What's being tested
- Biopsies
Intervention · OTHER
Biopsy will be done on the Vastus Lateralis muscle in all groups
Study details
- Official title
- Mechanisms of Skeletal Muscle Proteolysis With Ethanol Consumption: an Integrated Molecular Metabolic Approach
- Sponsor
- The Cleveland Clinic
- Conditions
- Alcoholic Liver Disease
- Enrolling
- 40 people
- Starts
- 2015-05-18
- Est. completion
- 2027-12-31
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 65 YearsSex ALLHealthy volunteers AcceptedAll participants
You may qualify if
- Alcoholic liver disease:
- Clinical, biochemical, imaging criteria and liver biopsy where available
- Age 18 - 65 years old
You can't join if
- For both groups - alcoholic liver disease and controls:; Poorly controlled diabetes mellitus (HbA1C>9.5 g/dl); Untreated Hyper- / hypo- thyroidism; Patients on dialysis, renal disease with serum creatinine 1.5 mg/dL; Active intravenous drug use; History of bowel surgery or gastric bypass surgery; Medications known to alter muscle protein metabolism (i.e. corticosteroids, tamoxifen, high-dose estrogen, testosterone or anabolic steroids); Metastatic disease, Advanced cardiac or pulmonary disease; Pregnancy; Coagulopathy- INR >1.4 and platelet count <80,000/ml.
Controls
You may qualify if
- Serum liver transaminases (i.e. ALT and AST) 40 IU/L
- Normal liver ultrasound
- Age 18 - 65 years old
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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1
Study locations (1)
1 openCleveland Clinic
Cleveland, Ohio, United States
- Revathi Penumatsa · Contact216-445-0688penumar@ccf.org
- Annette Bellar · Contact2166365247bellara@ccf.org
Recruiting
Study team
Sponsor
The Cleveland Clinic
Study ID 14-1287
Principal investigator
Srinivasan Dasarathy, MD
The Cleveland Clinic
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.