Ketamine with midazolam for brain protection after acute ischemic stroke

You may qualify if

• All patients who are 18 years or older, presenting or admitted to the study site with acute ischemic stroke, up to 24 hours since their last known well time
• An MRI evidence of acute ischemic infarct on the diffusion-weighted imaging with ADC correlate
• Pre-stroke modified Rankin scale of 0-2
• Patient should be willing to participate in the study by providing a written consent himself/herself or through a proxy.

You can't join if

• Eligibility to receive IV Alteplase or intra-arterial thrombectomy/embolectomy
• Longer than 24 hours since last known well time
• Pre-stroke modified Rankin scale of 3 or above.
• Pregnant or lactating females
• Pre-existing psychiatric illness
• Intracranial hemorrhage of any type at presentation
• Seizure at onset of symptoms
• Sustained uncontrolled hypertension defined as Systolic Blood pressure greater than 185 mmHg or Diastolic Blood Pressure greater than 110 mmHg, despite administration of antihypertensive medications
• Known hypersensitivity or adverse reaction to prior administration of Ketamine
• Inability/refusal to provide consent by the patient or through a proxy