What this study is
To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.
What's being tested
- blood draw and muscle biopsy
Intervention · PROCEDURE
One venous catheter will be used for bolus injection of multiple labeled AA at the beginning .The second venous catheter will inserted in the other arm for 5 ml of arterialized venous blood draw.Following the infusions, a single muscle biopsy will be performed from the vastus lateralis of the thigh using the Bergstromm needle.
Study details
- Official title
- Multiple Tracer Using Single Muscle Biopsy Technique in Evaluating Protein Synthesis and Break Down in Muscles of Cirrhotic Patients
- Sponsor
- The Cleveland Clinic
- Conditions
- Cirrhosis
- Enrolling
- 20 people
- Starts
- 2017-08-03
- Est. completion
- 2028-09-30
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria.
- Patients with Child Pugh score from A5- to B7
- Control group: Subject in control group should have serum ALT and AST within normal range.
- Exclusion Criteria for both groups (cirrhotic and control) are:; diabetes; cancer; kidney failure; pregnancy; recent surgery (bowel resection or Gastric bypass operation); Advanced cardiac or pulmonary disease; patient with thyroid disease & Coagulopathy ( INR >1.4 and platelet count <80,000/ml)
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
Study locations (1)
1 openCleveland Clinic Foundation
Cleveland, Ohio, United States
- Annette Bellar, MSLA · Contact216-445-0688bellara@ccf.org
Recruiting
Study team
Sponsor
The Cleveland Clinic
Study ID 14-1476
Principal investigator
Srinivasan Dasarathy, MD
The Cleveland Clinic
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.