What this study is
This study proposes to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath by comparing the natural abundances of 2H:1H and 18O:16O in saliva and urine of un-dosed humans.
What's being tested
- Feasibility of measuring 2H:1H and 18O:16O in saliva and breath.
Intervention · PROCEDURE
The investigators propose to demonstrate the feasibility of measuring 2H:1H and 18O:16O in saliva and breath. The natural abundances of 2H:1H and 18O:16O of urine, saliva, and breath samples will be determined from samples obtained simultaneously from 50 relatively healthy human subjects. We will also measure 2H:1H and 18O:16O enrichments in urine, saliva, and breath of 10 relatively healthy human subjects obtained after consuming a standard DLW dose and compare the estimates of TDEE using these different matrices.
Study details
- Official title
- Rapid Measurements of Water Isotopes in Human Breath and Saliva for Doubly Labeled Water Analysis
- Sponsor
- University of Colorado, Denver
- Conditions
- Human Energy Expenditure
- Enrolling
- 60 people
- Starts
- 2018-02-27
- Est. completion
- 2026-12
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 45 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- Healthy adult men and women, aged 18-45 yrs
You can't join if
- Obesity (body mass index (BMI) > 30 kg/m2)
- Pregnant or lactating women
- Self-reported acute or chronic disease (diabetes, heart diseases, thyroid diseases)
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openEdward Melanson
Aurora, Colorado, United States
Study team
Sponsor
University of Colorado, Denver
Study ID 16-2203
Principal investigator
Edward L Melanson, PhD
University of Colorado, Denver
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.