What this study is
This study aims to develop and evaluate biomarkers using non-invasive optical coherence tomography (OCT) and OCT angiography (OCTA) as well as ultra-widefield (UWF) fundus photography to assess the structure and function of the retinal and choroidal microvasculature and structure in persons with mild cognitive impairment (MCI) and Alzheimer's Disease (AD), Parkinson's Disease (PD), or other neurodegenerative disease, diseases as outlined.
What's being tested
- Retinal and Choroidal Imaging
Intervention · DEVICE
Non-invasive OCT, OCTA, and UWF fundus photography of retina
Study details
- Official title
- Evaluating the Retinal and Choroidal Microvasculature and Structure Using Multimodal Retinal and Choroidal Imaging in Neurodegenerative Disease: iMIND Research Study
- Sponsor
- Duke University
- Conditions
- Alzheimer's Disease · Mild Cognitive Impairment · Parkinson's Disease · Multiple Sclerosis · Huntington Disease · Lewy Body Dementia · Frontotemporal Dementia · Amyotrophic Lateral Sclerosis (ALS) · APOE-4 Positive · Traumatic Brain Injury · Concussion · Post-Traumatic Stress Disorder · Down Syndrome · Neuro-Degenerative Disease · Normal Cognition
- Enrolling
- 2,000 people
- Starts
- 2017-07-20
- Est. completion
- 2026-12-31
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers AcceptedYou may qualify if
- Adults with neurodegenerative disease ((MCI, PD, AD, FTD, DLB, ALS, MS, HD, TBI, concussion, PTSD and other neurodegenerations as well as Down Syndrome)
- Adults without neurodegenerative disease
You can't join if
- Inability to cooperate with or complete testing or other neurologic or age- related ocular conditions that would impact image acquisition.
- Eyes that have had intraocular surgery, other than cataract surgery. If two eyes satisfy the inclusion criteria, both eyes will be included in the study. If one eye satisfies the inclusion criteria, the eye that qualifies will be included in the study.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openDuke University Medical Center
Durham, North Carolina, United States
- Sharon Fekrat, MD FACS FASRS · Contact919-681-3937imind@duke.edu
Recruiting
Study team
Sponsor
Duke University
Study ID Pro00111831
Principal investigator
Sharon Fekrat, MD FACS FASRS
Duke University
Principal investigator
Dilraj Grewal, MD
Duke University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.