What this study is
Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level.
Subjects will participate in a clinical interview (Day 1), and then tasks+EEG (Day 2). Day 1 will be 4 hours or less, and Day 2 will be 2.5 hours or less.
What's being tested
- Beads Task
Intervention · BEHAVIORAL
Participants will be asked to make a series of decisions that involve combining information about the value and probability of potential rewards. Subjects will sit in front of a computer monitor and place their hand over a box with orange and blue button that they will be asked to press based on their idea of which one will be the majority in a jar full of orange and blue beads. This task should take 15-20 minutes to complete, not including EEG setup.
- PROVOC Tasks
Intervention · BEHAVIORAL
Three tasks will be developed collaboratively with the participant and independent evaluator that involve the participant being exposed to triggers that are considered by him/her impossible to confront without ritualizing. There will also be a similar process involving objects that should not cause any distress to be used as a control. Sessions will be videotaped with AFAR system concurrent to recording of LFPs from VS and scalp EEG.
Study details
- Official title
- Locating Biomarkers of Medically Intractable Obsessive Compulsive Disorder (OCD) Through the Use of Behavioral Tasks
- Sponsor
- Baylor College of Medicine
- Conditions
- OCD · Obsessive-Compulsive Disorder
- Enrolling
- 20 people
- Starts
- 2026-03
- Est. completion
- 2026-03
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 65 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Diagnosis of OCD
- Non-pregnant if female
- Minimum score of 16 on Y-BOCS
- Ability to provide informed consent
You can't join if
- Those not meeting inclusion criteria listed above
- Lifetime diagnosis of psychotic disorders such as schizophrenia
- Alcohol or substance abuse/dependence within 6 months, excluding nicotine
- Deemed at high risk of suicidal behavior or impulsivity
- Pregnant or plans to become pregnant in the next 24 months
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (3)
3 openUniversity of Pittsburgh
Pittsburgh, Pennsylvania, United States
Brown University
Providence, Rhode Island, United States
Baylor College of Medicine
Houston, Texas, United States
- Clarissa Aguilar · Contact(713) 798-3080Clarissa.Aguilar@bcm.edu
- Gregory Vogt · Contact(713) 798-4729gsvogt@bcm.edu
- Wayne K Goodman, MD · Principal investigator
- Raymond Cho, MD, PhD · Sub-investigator
- Nithya Ramakrishnan, MS · Sub-investigator
- Eric Storch, PhD · Sub-investigator
- Elizabeth McIngvale, PhD · Sub-investigator
- Gregory Vogt · Sub-investigator
Study team
Sponsor
Baylor College of Medicine
Study ID H42237
Principal investigator
Wayne Goodman, MD
Baylor College of Medicine
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.