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Carotid Artery DiseasesCognitive functionDiagnostic testProcedure

What this study is

Decreased blood flow to the brain can cause decreased cognitive function. Carotid disease can result in decreased blood flow to the brain. The investigators seek to assess this relationship prospectively through performing a battery of neurocognitive assessments, collection of serum markers of inflammation, and through neuroimaging at two points before intervention (2 months and 1 month before stenting) and at two points after intervention (1 month and 2 months after intervention). The goal is to provide prospective evidence to identify the extent to which carotid stenosis and hypoperfusion of the brain results in diminished neurocognitive performance, and see if serum biomarkers before and after stenting correlate with these findings.

What's being tested

  • Neurocognitive Assessments

    Intervention · DIAGNOSTIC TEST

    Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. Prior to surgery patients will undergo a battery of neurocogntive assessments 1 month and 2 months prior to surgery.

  • Measurements of inflammatory biomarkers

    Intervention · DIAGNOSTIC TEST

    Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis. After surgery, patients will undergo blood draws to measure for inflammatory biomarkers.

  • Carotid Artery Stenting

    Intervention · PROCEDURE

    Patients will undergo carotid artery stenting for 50-70% carotid artery stenosis.

Study details

Sponsor
University of California, San Diego
Conditions
Carotid Artery Diseases · Neurocognitive Dysfunction
Enrolling
20 people
Starts
2021-07-15
Est. completion
2025-12
Design
Open-label, non-randomized, parallel groups
Record
View on ClinicalTrials.gov ↗