HealthyDiagnostics and screeningHealthy volunteers
What this study is
This pilot study will first establish the feasibility of an in vivo methodology of assessing the utilization of glutamine into the TCA cycle of normal bone marrow plasma cells from healthy subjects while comparing it to an ex vivo approach
What's being tested
- 5-13C-Glutamine
Intervention · OTHER
Intravenous infusion of 5-13C-Glutamine
- Bone marrow aspiration
Intervention · OTHER
Bone marrow aspiration of bone marrow aspirate
Study details
- Official title
- In Vivo Assessment of Glutamine Utilization by Bone Marrow Plasma Cells in Healthy Subjects Using Stable Isotope Resolved Metabolomics: A Pilot Study
- Sponsor
- Mayo Clinic
- Conditions
- Healthy
- Enrolling
- 20 people
- Starts
- 2017-09-01
- Est. completion
- 2026-01
- Design
- Open-label, non-randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 60 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- Ages 18-60
- Able to provide written consent
You can't join if
- Renal Failure
- Pregnancy
- Active steroid use
- Active liver Disease
- Anemia (Hemoglobin < 12.5 g/dL in men and < 11.5 g/dL in women)
- H/O alcohol use (average > 2 drinks per day)
- BMI > 30
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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1
Study locations (1)
1 openMayo Clinic
Rochester, Minnesota, United States
- Wilson Gonsalves, MD · Contact5072842511gonsalves.wilson@mayo.edu
Recruiting
Study team
Sponsor
Mayo Clinic
Study ID 16-008291
Principal investigator
Wilson Gonsalves, MD
Mayo Clinic
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.