An imaging agent (18F-MK-6240) for tau PET scans in adults with diabetes or pre-diabetes

You may qualify if

• Age 55 to 69 years
• Without dementia
• Fluent in English and/or Spanish.
• Living in Northern Manhattan.
• Self-identified as Hispanic, non-Hispanic Black, or non-Hispanic White.
• Already had or agreed to have a brain MRI and Florbetaben PET.
• Able to participate in all scheduled evaluations and to complete all required tests and procedures.

You can't join if

• Dementia diagnosis
• Certain significant medical conditions, which make study procedures of the current study unsafe. Such serious medical conditions include uncontrolled epilepsy and multiple serious injuries.
• Persons with serious chronic conditions (e.g. Liver Cirrhosis, renal failure), which, in the opinion of the investigator, could increase the risk of un-anticipated adverse events.
• Contraindication to MRI scanning
• Conditions precluding entry into the scanners (e.g. morbid obesity, claustrophobia, etc.).
• Inability to have a catheter in subject's vein for the injection of radioligand.
• Inability to have blood drawn from subject's veins.
• Women in the age group that we are recruiting are highly unlikely to be pre-menopausal, and thus, highly unlikely to be menstruating. However, we will ask all women if they are post-menopausal, and in the rare case that they are not, we will conduct a urine pregnancy test to rule out pregnancy. Breastfeeding women will be excluded, although we expect this situation to be rare