What this study is
The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients.
The specific aims are as follows:
1. Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use. 2. Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.
What's being tested
- Desonide 0.05%
Intervention · DRUG
Desonide 0.05% ointment topically twice daily for two weeks
- Ketoconazole 2%
Intervention · DRUG
Ketoconazole 2% cream topically twice daily for two weeks
Study details
- Official title
- Alterations in the Human Microbiome With Commonly Used Topical Medications
- Sponsor
- University of California, Davis
- Conditions
- Healthy
- Enrolling
- 24 people
- Starts
- 2013-01-28
- Est. completion
- 2026-09-28
- Design
- Double-blind, randomized, parallel groups, Phase 1
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers AcceptedYou may qualify if
- Adults at least 18 years of age.
You can't join if
- Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions.; Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded.
- Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months
- Individuals with known allergies to any of the study medications.
- Individuals younger than 18 years of age.
- Adults unable to consent
- Non-English speaking individuals. Given the complexity in the instructions that subjects will need to follow for proper sample collection, we will not seek to recruit non-English speaking individuals for this pilot study.
- Prisoners
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
Study locations (1)
1 openUniversity of California, Davis, Department of Dermatology
Sacramento, California, United States
- Emanual Maverakis, MD · Contact916-734-8254emaverakis@ucdavis.edu
- Lauren Downing · Contact916-551-2635ldowning@ucdavis.edu
Recruiting
Study team
Sponsor
University of California, Davis
Study ID 390406
Principal investigator
Emanual Maverakis, MD
UC Davis
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.