Hyperpolarized carbon-13 pyruvate MRI to detect brain metabolism changes after traumatic brain injury

You may qualify if

• 18 through 60 years of age.
• Ability to understand the the willingness to sign a writteninformed consent.
• All races and ethnicities will be included; subjects must be able to read and speak either the English or Spanish language.
• TBI Patients
• Injury occurred within 30 days
• Documented and verified TBI by Glascow coma scal 10-15 and/or Loss of Consciousness >10 minutes.
• Head Computed Tomography at admission.

You can't join if

• Non-traumatic structural brain abnormality identified on head CT.
• Metallic foreign bodies on the scalp or cranium which may interfere with MRI acquisitions.
• Penetrating TBI.
• Significant anatomic distortion of the brain identified on CT images, such as large hematomas, herniation, intraventricular hemorrhage, extensive subarachnoid hemorrhage, hydrocephalus.
• Significant polytrauma that would interfere with follow-up and outcome assessment.
• Patients on psychiatric hold.
• Major debilitating mental health disorders including, but not limited to schizophrenia and bipolar disorder that would limit compliance with study requirements.
• Major debilitating neurological disease including, but not limited to, stroke, CVA, dementia and tumor that would limit compliance with study requirements.
• Under influence of illicit drugs which are known to alter brain physiology/metabolism including, but not limited to cocaine, lysergic acid diethylamide (LSD), and marijuana at the time of MRI/MRSI scanning.
• Any contraindication per MRI Screening Form including; Implants contraindicated at 3T, pacemakers; Implantable Cardioverter Defibrillator (ICD); Claustrophobia; Prisoners or patients in custody.; Medically unstable including; Heart failure; Severe left ventricular outflow tract (LVOT) obstruction; Unstable angina; Pregnancy; Lactating; Subjects who are receiving any other investigational agents.