What this study is
The purpose of this study is to gain more information about the step-by-step process that causes someone to develop type 1 diabetes. Scientists think that a person's own immune system, directed by genetic and environmental factors play a major role in its development. Participation involves a blood draw, a brief medical history questionnaire and measurements of height and weight. Some participants will be asked to return for annual follow-up visits for 10 years.
What's being tested
- Blood Collection
Intervention · OTHER
Blood will be collected via venipuncture and analyzed. Blood samples will be analyzed for HLA haplotype (a genetic sequence related to type 1 diabetes susceptibility), plasma-induced signature, diabetes autoantibodies, complete blood count with differential, and serum and plasma for storage. For family members with diabetes, blood will also be tested for A1c.
Study details
- Sponsor
- Medical College of Wisconsin
- Conditions
- Type1diabetes · Diabetes Mellitus, Type 1 · Type1 Diabetes Mellitus · Diabetes Mellitus
- Enrolling
- 4,000 people
- Starts
- 2001-08
- Est. completion
- 2050-01
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 2 Years and overSex ALLHealthy volunteers AcceptedFamilies
You may qualify if
- Families where at least one first-degree family member has type 1 diabetes
- The diabetic proband in the family was diagnosed before the age of 39
- Family members must be at least 2 years old to participate
You can't join if
- Families with no history of type 1 diabetes
- Families with a history of diabetes that is not type 1 (LADA, MODY, type 2 etc.)
Controls
You may qualify if
- No family history of type 1 diabetes or other autoimmune conditions
- Age 2 or older
You can't join if
- Personal or family history of autoimmune disease
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openMedical College of Wisconsin
Milwaukee, Wisconsin, United States
- Martin Hessner, PhD · Contact414-955-4903t1dinfo@mcw.edu
Recruiting
Study team
Sponsor
Medical College of Wisconsin
Study ID 142618
Principal investigator
Martin Hessner, PhD
Medical College of Wisconsin
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.