What this study is
The investigators will collect omental tissue (research surgical excision) and placental tissue (standard of care clinical delivery) from both preeclamptic and non-preeclamptic women during their c-section and use these samples to study the blood vessels, specifically the expression/activation of the AT2R.
What's being tested
- Omental Biopsy
Intervention · PROCEDURE
The surgeon and clinical care team will conduct the c-section to deliver the baby and the placenta as clinically indicated. After delivery, during the closing procedures, the surgeon will indicate a time for a participating Ob/Gyn physician on the study team to collect the omental bio-specimen. Omentum is frequently excised or removed for clinical reasons during surgical procedures. Omentum has small blood vessels within it that have been used for evaluation of vascular functional changes in research. The investigators wish to isolate one to three vessels of 5 to 7 cm length. The surgeon will then close and the clinical care team will resume their standard of care activities.
Study details
- Official title
- Angiotensin 2 Receptor (AT2R) Expression/Activation in Endothelial Cells in Preeclampsia
- Sponsor
- University of Wisconsin, Madison
- Conditions
- Pre-Eclampsia · Vascular Diseases
- Enrolling
- 166 people
- Starts
- 2018-11-20
- Est. completion
- 2027-04
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 40 YearsSex FEMALEHealthy volunteers AcceptedYou may qualify if
- Female
- Ages 18 to 40 years old
- Singleton gestation between 28 weeks, 0 days and 41 weeks, 0 days gestational age at the time of consent
- Undergoing caesarean section, either planned or otherwise with or without trial of labor
You can't join if
- Treatment of severe hypertension by antihypertensive or use of magnesium sulfate after the patient is hospitalized for the diagnosis of preeclampsia.
- Any major fetal structural anomalies or aneuploidies
- Undergoing cesarean section for placental abruption or bleeding complications.
- Singleton gestation not within 36 weeks, 0 days and 41 weeks, 0 days gestational age at the time of enrollment (delivery)
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUnityPoint Health-Meriter Hospital
Madison, Wisconsin, United States
- Sathish Kumar, PhD · Principal investigator
Recruiting
Study team
Sponsor
University of Wisconsin, Madison
Study ID 2025-1352
Principal investigator
Sathish Kumar, PhD
University of Wisconsin, Madison
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.