Skip to main content
Major Depressive DisorderSleepBehavioralChildren's healthBehavioral

What this study is

This study will evaluate whether a newer treatment, rumination-focused cognitive behavioral treatment, which includes mindfulness and can be used to reduce ruminative habits, change ways in which key brain regions interact with each other (e.g.., often called connectivity), and whether these changes in habits and brain connectivity can reduce the risk for recurrence of depression in the next two years.

What's being tested

  • Rumination-Focused CBT

    Intervention · BEHAVIORAL

    RF-CBT targets rumination and other maladaptive forms of emotion regulation such as suppression and avoidance and provides skills training in effectively coping with rumination. RF-CBT specifically targets rumination through psychoeducation, adopting a functional analytic approach to the learned habitual behavior of rumination, and a focus on shifting process style. The adolescent is taught to notice triggers to ruminate as well as the consequences of rumination and to shift into practicing a more adaptive strategy such as an attention training exercise, behavioral activation, thinking in a concrete way, or active problem-solving. RF-CBT directly teaches adolescents to recognize rumination or "when the participant gets stuck in their head" and to notice the influence this has on their mood.

  • Relaxation-based Therapy

    Intervention · BEHAVIORAL

    Sessions will include progressive muscle relaxation, simple breathing techniques, and guided imagery that focus on bodily and somatic relaxation. Adolescents randomized to Relaxation Therapy (RelaxT) will also receive exercises to do as homework in between sessions, parallel to the RF-CBT group.

Study details

Official title
Developing Rumination-focused Treatment to Reduce Risk for Depression Recurrence (RDR) in Adolescence
Sponsor
Ohio State University
Conditions
Major Depressive Disorder · Mood Disorders
Enrolling
183 people
Starts
2019-05-01
Est. completion
2029-03-02
Design
Double-blind, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗