What this study is
The investigators propose a new imaging method for children born with congenital anomalies of the urinary tract that is a rapid, injection-, sedation-, and radiation-free alternative: the quick renal MRI. This proposal hypothesizes that the quick renal MRI has high validity compared to current radiologic standard for renal infection and scarring, the 99mTechnetium-dimercaptosuccinic acid (99mTc- DMSA) renal scan in the detection of acute renal infections and scars. If the quick renal MRI is accurate, it could potentially replace the DMSA scan for those specific questions and ease the burden of testing for children with chronic renal disease. Findings from these studies will provide preliminary data and rationale for a multi-centered study to further test this new technology.
Participants will be 0-21 years of age and can expect to be on study for from 1 week (if enrolled in Aim 1) to 6 months (if enrolled in Aim 2).
What's being tested
- Quick MRI
Intervention · DIAGNOSTIC TEST
A quick MRI scan takes about 15 mins or less. No IV or sedation will be necessary. The participant will be required to lie flat and still during the test. A parent will be allowed to be with the participant while they are in the scanner. The machine will produce loud intermittent sounds of banging or knocking so they will have to wear protective headphones. They can listen to music if they would like. If they are less than 1 year old, they will be swaddled and can be "held" during the test. If a child needs to have a parent in the scanner, it is ideal if the parent can have their head near the participant's legs and arms stretched out to hold the child's hands. If the parent needs to be by the patient's head, it can be accomplished by the parent lying head to head with the child or the parent lying on the child. Ideally they are lying head to head, or just outside of the scanner reaching in.
Study details
- Sponsor
- University of Wisconsin, Madison
- Conditions
- Pyelonephritis · Pyelonephritis Acute · Renal Sclerosis
- Enrolling
- 100 people
- Starts
- 2019-05-07
- Est. completion
- 2025-01
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 0 Years – 21 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Aim 1:
- Patient is admitted to American Family Children's Hospital for a febrile UTI, suspected pyelonephritis, or diagnosed pyelonephritis
- Undergoing clinical DMSA scan
- Aim 2:
- Undergoing DMSA scans as a part of their routine clinical care
- History of more than one UTI in the past year
You can't join if
- Aim 1:
- No evidence of pyuria on their urine analysis
- Negative urine culture
- Not comfortable with having a Quick MRI performed
- Both aims:
- Contraindications to MRI
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openAmerican Family Children's Hospital
Madison, Wisconsin, United States
- Jennifer Wang · Contact608-265-3834jtwang@ortho.wisc.edu
Recruiting
Study team
Sponsor
University of Wisconsin, Madison
Study ID 2018-0492
Principal investigator
Shannon Cannon, MD
University of Wisconsin, Madison
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.