Comparing high-protein diets from animal and plant sources for insulin sensitivity and blood sugar control

You may qualify if

• Age: ≥21 and ≤70 years;
• BMI: >24.5 and <32.5 kg/m2;
• Habitual protein intake <0.9 g/kg/day (assessed on 2 weekdays and 2 weekend days by using the HealthWatch 360 app); and
• Weight stable (i.e., ≤3% change) and untrained (≤150 min of structured exercise/week) for at least 2 months before entering the study.

You can't join if

• Prediabetes or type 2 diabetes;
• Evidence of chronic kidney disease by medical history or laboratory tests (glomerular filtration rate <60 ml/min/1.73 m2 or an albumin to creatinine ratio in urine ≥30 mg/g);
• Vegetarians or vegans;
• Intolerance or allergies to ingredients in the metabolic meal or intervention diet;
• Take dietary supplements (e.g., pre- and probiotics, fiber, fish oil) or medications known to affect our study outcomes;
• Received antibiotic or antifungal treatment (which affect the microbiome and therefore microbial metabolite production) 2 months before entering the study;
• Consume tobacco products or excessive alcohol (women: >14 drinks/week; men: >21 drinks/week);
• Evidence of significant organ system dysfunction or diseases (e.g., cirrhosis), and
• Unwilling or unable to provide informed consent.