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Hepatic EncephalopathyNutrition and dietSupplementsDietary supplement

What this study is

Readmission rates for patients with hepatic encephalopathy due to end stage liver disease are high. Hyperammonemia contributes significantly to encephalopathy and occurs because of impaired hepatic ureagenesis and increased skeletal muscle proteolysis. We propose a randomized, 6-month nutritional intervention in cirrhotic patients who have had at least 1 admission for hepatic encephalopathy within the last 6 months. We hypothesize that a combination of late evening and early morning protein supplement (Ensure Enlive) will decrease recurrent hepatic encephalopathy and consequent readmission rates by lowering skeletal muscle proteolysis and improved lean body mass.

What's being tested

  • Ensure Enlive

    Intervention · DIETARY SUPPLEMENT

    The subjects in the intervention group will receive two Ensure Enlive supplements per day for 180 days.

  • Standard Of Care

    Intervention · OTHER

    The subjects in the Standard of care group will continue to receive the standard clinical therapy.

Study details

Sponsor
The Cleveland Clinic
Conditions
Hepatic Encephalopathy
Enrolling
40 people
Starts
2019-09-16
Est. completion
2028-10-30
Design
Single-blind, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗