What this study is
Demonstrate the relationship between DD-cfDNA levels and HLA antibodies in blood, and the Molecular Microscope® (MMDx) Diagnostic System results in indication biopsies.
What's being tested
- MMDx
Intervention · DIAGNOSTIC TEST
Portion of kidney transplant indication biopsy
- Prospera
Intervention · DIAGNOSTIC TEST
- HLA antibody
Intervention · DIAGNOSTIC TEST
Both Prospera and HLA antibody
Transplant patient blood sample
Study details
- Official title
- Trifecta-Kidney cfDNA-MMDx Study: Comparing the DD-cfDNA Test to MMDx Microarray Test, Central HLA Antibody Test, and Histology.
- Sponsor
- University of Alberta
- Conditions
- Kidney Transplant Rejection
- Enrolling
- 300 people
- Starts
- 2019-12-01
- Est. completion
- 2029-12
- Record
- View on ClinicalTrials.gov ↗
Who can join
Sex ALLHealthy volunteers Not acceptedYou may qualify if
- All kidney transplant recipients undergoing a kidney biopsy for clinical indications, as determined by their physician or surgeon, will be eligible to enroll in the study.
You can't join if
- Patients will be excluded from the study if they decline participation or are unable to give informed consent or multiple organ recipients.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (31)
27 openTampa General Hospital
Tampa, Florida, United States
- Natalie Remsen · Contactnremsen@tgh.org
- Rajendra Baliga, MD · Principal investigator
RecruitingUniversity of Maryland School of Medicine
Baltimore, Maryland, United States
- Raissa Toure · ContactRToure@som.umaryland.edu
- Jonathan Bromberg, MD PhD · Principal investigator
- Matt Weir, MD · Principal investigator
RecruitingThe Johns Hopkins University, School of Medicine
Baltimore, Maryland, United States
- Darin B Ostrander, PhD · Contact410-614-6702dostran1@jhmi.edu
- Daniel C Brennan, MD · Principal investigator
RecruitingDetroit Medical Center, Harper University Hospital of Wayne State University
Detroit, Michigan, United States
- Rajeev Sharma, MD · Contactrasharma@med.wayne.edu
- Rajeev Sharma, MD · Principal investigator
- Mareena Zachariah, MD · Sub-investigator
Not yet recruitingHenry Ford Hospital
Detroit, Michigan, United States
- Iman Francis · ContactIfranci1@hfhs.org
- Milagros Samaniego-Picota, MD · Principal investigator
- Iman Francis, MD · Sub-investigator
- Anita Patel, MD · Sub-investigator
RecruitingBarnes-Jewish Hospital, Washington University at St. Louis
St Louis, Missouri, United States
- Andrew Malone · Contactamalone@wustl.edu
- Andrew Malone, MD PhD · Principal investigator
- Tarek Ahamad, MD · Sub-investigator
RecruitingUniversity Hospitals Cleveland Medical Ctr.
Cleveland, Ohio, United States
- Katherine R Carter · ContactKatherine.carter@uhhospitals.org
- Jittirat Arksarapuk, MD · Principal investigator
RecruitingCleveland Clinic
Cleveland, Ohio, United States
- Debra Camino · Contactcaminod@ccf.org
- Emillio Poggio, MD · Principal investigator
- Richard Fatica, MD · Principal investigator
- Ziad Zaky, MD · Principal investigator
RecruitingIntermountain Transplant Services
Murray, Utah, United States
- Jake Krong · ContactJake.Krong@imail.org
- Sanjiv Anand, MD · Principal investigator
RecruitingVirginia Commonwealth University Medical Center
Richmond, Virginia, United States
- Gaurav Gupta, MD · Contactggupta@mcvh-vcu.edu
- Gaurav Gupta, MD · Principal investigator
- Layla Camal, MD · Principal investigator
RecruitingDivision of Nephrology & UW Organ Transplant Center University of Washington
Seattle, Washington, United States
- Chris Blosser, MD · ContactCBlosser@nephrology.washington.edu
- Chris Bosser, MD · Principal investigator
Recruiting
20 sites outside the US
Department of Nephrology, The Royal Melbourne Hospital 1 South East
Melbourne, Australia
- Peter D Hughes, MD · Contactpeter.hughes@mh.org.au
- Kevin Chow, MD · Principal investigator
- Peter D Hughes, MD · Sub-investigator
RecruitingUniversity of Alberta, Department of Medicine
Edmonton, Alberta, Canada
- Soroush Shojai, MD · Contactshojai@ualberta.ca
- Soroush Shojai, MD · Principal investigator
- Sita Gourishankar, MD · Sub-investigator
- Majid Sikosana, MD · Sub-investigator
RecruitingST. Paul's Hospital, 6A Providence Building, 1081 Burrard Street
Vancouver, British Columbia, Canada
- Angela Ogniben · ContactAOgniben@providencehealth.bc.ca
- John S Gill, MD, MS · Principal investigator
RecruitingUniversity Hospital Merkur Renal Division
Zagreb, Croatia
- Zeljka Jurekovic, MD · Contactzeljka.jurekovic@gmail.com
- Mladen Knotek, MD · Principal investigator
- Zeljka Jurekovic, MD · Sub-investigator
- Ksenija Vucur, MD · Sub-investigator
RecruitingInstitute for Clinical and Experimental Medicine (IKEM)
Prague, Czechia
- Petra Hruba, MD · Contacthrup@ikem.cz
- Ondrej Viklicky, MD · Principal investigator
- Petra Hruba, MD · Sub-investigator
- Silvie Rajnochová Bloudíčkova · Sub-investigator
RecruitingCharite-Medical University of Berlin Department of Nephrology
Berlin, Germany
- Klemens Budde, MD · Contactklemens.budde@charite.de
- Monique Greiner-Pol · Contactmonique.greiner-pol@charite.de
- Klemens Budde, MD · Principal investigator
RecruitingCentre of Nephrology, Vilnius University Hospital Santaros Klinikos
Vilnius, Lithuania
- Alvita Vickiene · Contactalvita.gincaite@gmail.com
- Marius Miglinas, MD · Principal investigator
RecruitingMedical University of Gdańsk Klinika Nefrologii Transplantologii i Chorób Wewnętrznych
Gdansk, Poland
- Andrzej Chamienia, MD · Contactchamien@gumed.edu.pl
- Alicja Dębska-Ślizień, MD · Principal investigator
- Joanna Konopa, MD · Sub-investigator
- Andrzej Chamienia, MD · Sub-investigator
RecruitingMedical University of Silesia
Katowice, Poland
- Grzegorz Piecha, MD · Contactg.piecha@outlook.com
- Grzegorz Piecha, MD · Principal investigator
RecruitingDepartment of Transplantation and General Surgery, Wojewodzki Hospital
Poznan, Poland
- Maciej Glyda, MD · Contactglydam@wp.pl
- Maciej Glyda, MD · Principal investigator
- Katarzyna Smykal-Jankowiak, MD · Sub-investigator
RecruitingDepartment of Nephrology, Transplantation and Internal Medicine, University Hospital n.2
Szczecin, Poland
- Leszek Domański, MD · Contactdomanle@pum.edu.pl
- Leszek Domański, MD · Principal investigator
RecruitingPomeranian Medical University, Samodzielny Publiczny Woj. Szpital Zespolony, Oddzial Nefrologii i Transplantacji Nerek
Szczecin, Poland
- Marek Myślak, MD Phd · Contactmarek.myslak@pum.edu.pl
- Marek Myślak, MD PhD · Principal investigator
- Joanna Mazurkiewicz, MD · Sub-investigator
- Marta Gryczman, MD · Sub-investigator
RecruitingMedical University of Warsaw, Department of Transplantation Medicine, Nephrology and Internal Diseases
Warsaw, Poland
- Magdalena Durlik, MD · Contactmagdalena.durlik@wum.edu.pl
- Magdalena Durlik, MD · Principal investigator
RecruitingTransplant Medicine & Nephrology Clinic, Medical University of Warsaw
Warsaw, Poland
- Agnieszka Perkowska-Ptasińska, MD PhD · Contactaggape@poczta.onet.pl
- Agnieszka Perkowska-Ptasińska, MD PhD · Principal investigator
- Dominika Dęborska-Materkowska, MD · Sub-investigator
- Michał Ciszek, MD · Sub-investigator
RecruitingWroclaw Medical University, Department of Nephrology and Transplantation Medicine
Wroclaw, Poland
- Mirosław Banasik, MD · Contactm.banasik@interia.pl
- Mirosław Banasik, MD · Principal investigator
RecruitingDepartment of Nephrology, University Medical Centre
Ljubljana, Slovenia
- Nika Kojc, MD · Contactnika.kojc@mf.uni-lj.si
- Miha Arnol, MD · Principal investigator
- Nika Kojc, MD · Sub-investigator
RecruitingDepartment of Nephrology and Transplantation Medical University in Bialystok
Bialystok, Poland
CompletedUniversity Hospital nr1 Bydgoszcz, Klinika Transplantologii
Bydgoszcz, Poland
CompletedThe Children's Memorial Health Institute, Department of Nephrology, Kidney Transplantation and Hypertension
Warsaw, Poland
CompletedUniversity Hospital Zurich
Zurich, Switzerland
Completed
Study team
Sponsor
University of Alberta
Study ID ATAGC05
Principal investigator
Philip F Halloran, MD, PhD
University of Alberta
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.