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DepressionBehavioralDevice

What this study is

Depression is more common after a spinal cord injury (SCI) than in the general population. Unfortunately, it is unknown how depression is typically treated in individuals with SCI or if commonly used treatment methods are effective. This study will investigate the safety and impact of a novel method for treating depression called repetitive transcranial magnetic stimulation (rTMS). rTMS is a type of non-invasive brain stimulation. Fourteen individuals with a cervical or thoracic level SCI and depression will complete an approved treatment plan using rTMS. Participants will be treated using rTMS five days a week for four weeks. After four weeks of treatment, the study team will review the safety of rTMS and assess changes in depressive symptoms. If the results are positive, larger studies can be designed to develop better treatment options for individuals with SCI and depression.

What's being tested

  • rTMS

    Intervention · DEVICE

    The study team will deliver rTMS five days a week for four weeks, according to a specific and approved protocol for participant positioning, motor threshold determination, and dosing.

Study details

Official title
Treatment of Depression Post-SCI: Retrospective Analysis and Feasibility Trial
Sponsor
Medical University of South Carolina
Conditions
Depression · Spinal Cord Injuries
Enrolling
14 people
Starts
2026-02
Est. completion
2029-09
Design
Open-label, single group
Record
View on ClinicalTrials.gov ↗