What this study is
The focus of this proposal is on overweight (25>BMI<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.
What's being tested
- Weight loss surgery
Intervention · PROCEDURE
Severely obese women (BMI >40) undergo sleeve gastrectomy
Study details
- Sponsor
- East Carolina University
- Conditions
- Metabolic Inflexibility
- Enrolling
- 100 people
- Starts
- 2020-03-03
- Est. completion
- 2025-12
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 50 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- 18-50 years old
- BMI of 25 - 30 kg/m2
- BMI > 40kg/m2
- Lactate levels in top and lower 25%
You can't join if
- Pregnant women
- Mentally disabled
- Prisoners
- Smokers
- Subjects with heart disease
- Type 1 and 2 diabetes
- Endocrine disease
- Hypertension
- Musculoskeletal disease
- Peripheral occlusion
- Hepatic disease
- Have had weight fluctuations exceeding + 3% in the previous 12 months
- On medications which alter carbohydrate metabolism will not be studied
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openEast Carolina University
Greenville, North Carolina, United States
- Terry Jones, PhD · Contact2527446249joneste@ecu.edu
- Nicholas Broskey, PhD · Contact2527374684broskeyn19@ecu.edu
Recruiting
Study team
Sponsor
East Carolina University
Study ID UMCIRB 19-000914
Principal investigator
Joseph Houmard, PhD
East Carolina University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.