What this study is
This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.
What's being tested
- Controlled Diet
Intervention · OTHER
Participants will consume a controlled low oxalate diet for five days.
Study details
- Sponsor
- University of Alabama at Birmingham
- Conditions
- Kidney Stone · Urolithiasis, Calcium Oxalate
- Enrolling
- 4 people
- Starts
- 2027-07-01
- Est. completion
- 2032-08-01
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- At least 18 years of age
- History of calcium oxalate stones
- Heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel
- Willingness to comply with a controlled diet for five days
You can't join if
- Pregnant individuals
- Individuals who are currently breast feeding
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
Loading treatment details…
Study locations (1)
1 openUniversity of Alabama at Birmingham
Birmingham, Alabama, United States
Study team
Sponsor
University of Alabama at Birmingham
Study ID IRB-300005327
Principal investigator
Kyle Wood, MD
University of Alabama at Birmingham
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.