What this study is
62 patients who are one year post stroke and have Aphasia as a result of that stroke will be recruited. Participants will have 4 assessment sessions and 15 treatment sessions. The TDCS will be to right Inferior Frontal Gyrus (IFG) (25 active, 25 sham) for 15 days. A combined semantic feature analysis/phonological components analysis treatment will be paired with the stimulation. Two assessment sessions will be pretreatment, 1 session immediately post-treatment, and 1 session at 3 months follow-up.
What's being tested
- Active Comparator: Experimental: Active cathodal tDCS + language training
Intervention · DEVICE
Cathodal tDCS raises neuronal membrane potentials, leading to decreased probability of depolarization from incoming stimuli. Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment.
- Sham Comparator: Placebo cathodal tDCS + Speech and language
Intervention · BEHAVIORAL
Speech and Language training involves a combined semantic feature analysis and phonological components analysis treatment. .
Study details
- Official title
- Targeted Transcranial Direct Current Stimulation to Enhance Speech-Language Treatment Outcome in Persons With Chronic Post-Stroke Aphasia
- Sponsor
- University of New Mexico
- Conditions
- Stroke · Aphasia
- Enrolling
- 50 people
- Starts
- 2022-10-18
- Est. completion
- 2027-04-30
- Design
- Quadruple-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 25 Years – 85 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Aged 25-85
- Must be greater than 6 months post-stroke
- Must have a diagnosis of aphasia based on impaired performance on the Western Aphasia Battery-Revised, Boston Naming Test, or during discourse production
- Must be left-hemisphere dominant as demonstrated by aphasia onset subsequent to left hemisphere damage
- Must be stimulable for naming
You can't join if
- Comorbid neurological disease.
- Damage to the anterior right hemisphere.
- Significant mood disorder.
- Substance/alcohol dependence or abuse within the past year
- Presence of any implanted electrical device or contraindications to tDCS or MRI
- Recent medical instability (within 4 weeks)
- Pregnancy
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of New Mexico Center for Brain Recovery and Repair
Albuquerque, New Mexico, United States
- Darbi Gill · Contact505-925-4043DMGill@salud.unm.edu
Recruiting
Study team
Sponsor
University of New Mexico
Study ID UNM HRRC #16-091
Principal investigator
Jessica Richardson, Ph.D.
University of New Mexico
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.