Pain, PostoperativePainChildren's healthHealthy volunteers
What this study is
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
Study details
- Official title
- Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus
- Sponsor
- Boston Children's Hospital
- Conditions
- Pain, Postoperative · Pain, Chronic · Pain, Acute · Surgical Injury · Surgical Wound · Cornea Injury · Cornea · Keratoconus
- Enrolling
- 60 people
- Starts
- 2021-10-04
- Est. completion
- 2027-12
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 8 Years – 35 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- CXL Group
- Age 8-35 years
- Clinical diagnosis of keratoconus and seeking CXL treatment
- English speaking ability sufficient to comprehend consent with parental assistance
- MRI compatible
- Ability to lie still for an MRI session (60 minutes) Control Group
- Age 8-35 years
- No diagnosis of keratoconus
- English speaking ability sufficient to comprehend consent with parental assistance
- MRI compatible
- Ability to lie still for an MRI session (60 minutes)
You can't join if
- Claustrophobic
- Weight > 285 lbs (weight limit of the MRI table)
- Significant medical history, including: Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes
- Magnetic implants or metal-containing tattoos on their chest or above
- Pregnancy
- History of contact lens wear
- Any allergic response to a numbing eyedrop in the past
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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1
Study locations (1)
1 openBoston Children's Hospital
Boston, Massachusetts, United States
- Nicholas J Pondelis, BA · Contact617-919-1895nicholas.pondelis@childrens.harvard.edu
Recruiting
Study team
Sponsor
Boston Children's Hospital
Study ID IRB-P00035185
Principal investigator
Eric A Moulton, OD PhD
Boston Children's Hospital
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.