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Fuchs Endothelial Corneal DystrophyVision and hearingDrugPhase 2

What this study is

This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.

What's being tested

  • N-acetyl cysteine (NAC) 10% solution

    Intervention · DRUG

    N-acetyl cysteine is a sterile, unpreserved eye drop containing 10% (100 mg/mL) of acetylcysteine.

  • N-acetyl cysteine (NAC) 20% solution

    Intervention · DRUG

    N-acetyl cysteine is a sterile, unpreserved eye drop containing 20% (200 mg/mL) of acetylcysteine.

  • Visine Dry Eye Relief eye drops

    Intervention · DRUG

    Visine Tears Dry Eye Relief artificial tears ophthalmic solution

Study details

Sponsor
Massachusetts Eye and Ear Infirmary
Conditions
Fuchs Endothelial Corneal Dystrophy
Enrolling
45 people
Starts
2020-09-16
Est. completion
2027-04-30
Design
Double-blind, randomized, parallel groups, Phase 2
Record
View on ClinicalTrials.gov ↗