What this study is
Currently the diagnosis of OA is based on radiographs and clinical findings, which is limited to detecting late-stage disease. There is a pressing, unmet clinical need for robust assessment of early changes in cartilage health. Towards this goal, extensive efforts are ongoing to develop quantitative MRI for cartilage matrix analysis. MR T1ρ and T2 relaxation times have shown to be promising imaging biomarkers for early cartilage degeneration and prediction of disease progression. However, many challenges remain to clinically applying these techniques, including lack of standardized acquisition and quantification methods, and long acquisition times. The study aims to develop novel, fast and reproducible MR T1ρ and T2 relaxation time imaging methods on MR systems from multiple vendors and establish a platform for standardization and cross validation of these measures as a tool for clinical trials using such techniques. Following method validation, patients at risk for osteoarthritis will be tested.
What's being tested
- MRI
Intervention · DIAGNOSTIC TEST
Observational Study of novel MR imaging and image processing techniques that will provide reliable and fully quantitative evaluation of inflammation, chronic structural changes and vascularity in healthy patients and patients with ACL injury.
Study details
- Sponsor
- Xiaojuan Li
- Conditions
- Bone Diseases, Infectious · Musculoskeletal Diseases · Joint Diseases · Osteoarthritis · ACL Tear · Cartilage Degeneration
- Enrolling
- 88 people
- Starts
- 2022-04-01
- Est. completion
- 2026-12-28
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 50 YearsSex ALLHealthy volunteers Not acceptedGroup 1
You may qualify if
- Age > 18
You can't join if
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
- Pregnancy.
Group 2
You may qualify if
- Age 18-50
You can't join if
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
- Pregnancy.
- History of osteoarthritis and inflammatory arthritis
- Previous injury and/or surgery on either knee
Group 3
You may qualify if
- Age 18-50
- Sustain an acute full ACL tear in one knee; the contralateral knee uninjured
- Undergo ACL reconstructions and standard rehabilitation
You can't join if
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
- Pregnancy.
- Inability to undergo standard pre- and post-injury/operative rehabilitation
Group 4
You may qualify if
- Age 18-50
You can't join if
- Contraindication to MRI such as severe claustrophobia and implanted devices such as neurostimulators, pacemakers, aneurysm clips etc.
- Pregnancy.
- History of osteoarthritis and inflammatory arthritis
- Previous injury and/or surgery on either knee
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openCleveland Clinic Foundation
Cleveland, Ohio, United States
- Xiaojuan Li, PhD · Contact510-685-3495lix6@ccf.org
Recruiting
Study team
Sponsor
Xiaojuan Li
Study ID 20-599
Principal investigator
Xiaojuan Li
Director, Program for Advanced Musculoskeletal Imaging
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.