What this study is
This trial investigates whether hyperpolarized magnetic resonance imaging (hpMRI) can predict treatment response in patients with thyroid cancer and other malignancies of the head and neck undergoing radiation therapy and/or receiving systemic therapy before surgery. An hpMRI is like a standard MRI but involves the use of an imaging contrast agent called hyperpolarized 13-C-pyruvate. Diagnostic procedures, such as hpMRI, may predict a patient's response to treatment and may help plan the best treatment.
What's being tested
- Hyperpolarized Carbon C 13 Pyruvate
Intervention · DRUG
Given IV
- Magnetic Resonance Imaging
Intervention · PROCEDURE
Undergo MRI
- Magnetic Resonance Imaging
Intervention · PROCEDURE
Undergo hpMRI
Study details
- Official title
- Pilot Study of Metabolic Guidance for Therapy in Patients With Thyroid Cancer and Other Malignancies of the Head and Neck
- Sponsor
- M.D. Anderson Cancer Center
- Conditions
- Thyroid Gland Carcinoma
- Enrolling
- 42 people
- Starts
- 2020-08-12
- Est. completion
- 2027-05-31
- Design
- Open-label, non-randomized, parallel groups, Phase 1
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers AcceptedYou may qualify if
- Be willing and able to provide informed consent
- Be informed of the investigational nature of this study
- Be diagnosed with thyroid cancer and other malignancies of the head and neck with intent for treatment
You can't join if
- Have a history of severe claustrophobia
- Have electrically, magnetically or mechanically activated implants that would preclude magnetic resonance imaging (MRI)
- Have a history of cardiac arrhythmia
- Have an allergy to Gadavist intravenous contrast
- Estimated glomerular filtration rate (eGFR) < 30
- If female, be pregnant or breast feeding at time of consent
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openM D Anderson Cancer Center
Houston, Texas, United States
- Stephen Y. Lai · Contact713-792-6528
- Stephen Y. Lai · Principal investigator
Recruiting
Study team
Sponsor
M.D. Anderson Cancer Center
Study ID 2020-0482
Principal investigator
Stephen Y Lai
M.D. Anderson Cancer Center
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.