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KeratoconusVision and hearingDevice

What this study is

The objective of this study is to measure the Brillouin biomechanical properties in keratoconic corneas and characterize biomechanical alterations that occur after corneal procedures that inherently strengthen or weaken the cornea by evaluating the change in Brillouin metrics before and after treatments.

What's being tested

  • Brillouin microscopy

    Intervention · DEVICE

    The Brillouin clinical instrument is comprised of three parts: a human interface, a laser-scanning confocal microscope, and an etalon-based spectrometer. The human interface is a modified ophthalmic slit-lamp instrument with chin support and headrest. The light source is a single longitudinal mode CW laser at 780 nm. A polarizing beam splitter and quarter-wave plate assembly sends the laser beam to the human interface. To focus light into the eye, a long-working distance microscope objective is used. Brillouin scattered light from the eye is collected with a single-mode optical fiber. For spectral analysis, a two-stage VIPA-etalon spectrometer configured with the cross-axis cascade principle and the spectrum is measured on a EM-CCD camera.

Study details

Sponsor
The Cleveland Clinic
Conditions
Keratoconus · Keratoconus, Unstable · Keratoconus, Stable
Enrolling
220 people
Starts
2021-06-01
Est. completion
2027-12
Record
View on ClinicalTrials.gov ↗