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Liver DiseasesGut health

What this study is

Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial. In sicker recipients, LT results in immediate survival, but poor medium-term survival rates in some studies. The scarcity of deceased donors obliges to maximize LT success. Alternative strategies, as living-donor LT, should be explored. LDLT has impressive results in Eastern centers, but it is restrained in Western countries, due to potential life-threatening complications in the donor.

What's being tested

  • Observational Protocol

    Intervention · OTHER

    The cohorts will be followed for one year after LT transplantation except for group 3 (1-year follow-up after inclusion)

Study details

Official title
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure (ACLF): iNdications and outComEs
Sponsor
European Foundation for Study of Chronic Liver Failure
Conditions
Liver Diseases · Liver Cirrhosis · Acute-On-Chronic Liver Failure · Liver Transplant; Complications
Enrolling
3,000 people
Starts
2021-07-08
Est. completion
2026-12-31
Record
View on ClinicalTrials.gov ↗