Lung Cancer, Nonsmall CellCancerLungs and breathingDrugPhase 1, Phase 2
What this study is
This is a research study to evaluate the safety and effectiveness of tocilizumab in combination with atezolizumab to treat non-small cell lung cancer.
What's being tested
- Atezolizumab
Intervention · DRUG
1200mg infusion
- Tocilizumab
Intervention · DRUG
Tocilizumab 6mg/kg or 4mg/kg infusion
Study details
- Official title
- A Phase Ib-II Trial of Tocilizumab and Atezolizumab in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Refractory to 1st Line Immune Checkpoint Inhibitor-Based Therapy
- Sponsor
- Abramson Cancer Center at Penn Medicine
- Conditions
- Lung Cancer, Nonsmall Cell
- Enrolling
- 28 people
- Starts
- 2023-07-25
- Est. completion
- 2027-09
- Design
- Open-label, single group, Phase 1, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Advanced non-squamous NSCLC (Stage IV or recurrent after initial curative intent therapy) in adults age 18 or older
- Prior exposure to at least 1 line of therapy
- Exposure to a including checkpoint inhibitor in line of therapy immediately prior to enrollment on trial
- ECOG PS 0-2
You can't join if
- Presence of a driver mutation that is susceptible to targeted therapy
- No greater than CTCAE v5 grade 3 toxicity attributed to prior immunotherapy
- Other active invasive malignancy requiring ongoing therapy
- Evidence of progressing or untreated brain metastases
- Evidence or history of leptomeningeal disease
- Uncontrolled tumor related pain
- History of an autoimmune disease or IPF
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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1
Study locations (1)
1 openAbramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
- Mel V, BA · Contact215-220-9703Melissa.volpe@pennmedicine.upenn.edu
- Melina Marmarelis, MD, MSCE · Principal investigator
Recruiting
Study team
Sponsor
Abramson Cancer Center at Penn Medicine
Study ID UPCC 16520
Principal investigator
Melina Marmarelis, MD, MSCE
Abramson Cancer Center at Penn Medicine
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.