What this study is
Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.
What's being tested
- Ultrasound
Intervention · DIAGNOSTIC TEST
2D ultrasound image collection
- Biomarker Analysis
Intervention · DIAGNOSTIC TEST
Inflammatory and nutritional biomarker analysis
- Frailty Index
Intervention · OTHER
A Frailty Index Questionnaire be completed by patients or their surrogates to determine the presence of frailty at ICU admission
Study details
- Official title
- Identifying Modifiable PAtient Centered Therapeutics Frailty: An Observational Cohort Study
- Sponsor
- University of California, Los Angeles
- Conditions
- Frailty · Sarcopenia
- Enrolling
- 250 people
- Starts
- 2023-09-22
- Est. completion
- 2026-07
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
- ICU stay longer than 24 hours
You can't join if
- Patients with muscular or mitochondrial diseases affecting muscle quality or mass
- Preexisting paralysis
- Absence of lower limbs
- Ongoing discussions about goals of care
- Transfers from a skilled nursing facility
- Children under the age of 18
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openRonald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine
Los Angeles, California, United States
- Jennifer Scovotti, MA · Contact3102064484jscovotti@mednet.ucla.edu
- Cecilia Canales, MD, MPH · Principal investigator
- Maxime Cannesson, MD, Ph.D · Sub-investigator
- Vadim Gudzenko, MD · Sub-investigator
- Sumit Singh, MD · Sub-investigator
Recruiting
Study team
Sponsor
University of California, Los Angeles
Study ID 20-002271
Principal investigator
Cecilia Canales, MD, MPH
UCLA Department of Anesthesiology and Perioperative Medicine
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.