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Parkinson DiseaseCognitive function

What this study is

The purpose of this study is to investigate the brain activity associated with non-motor symptoms of movement disorders, including Parkinson's disease and essential tremor. These movement disorders commonly have significant non-motor features also, including depression, cognitive impairment, decreased attention, and slower processing speeds. The investigators are interested in the brain activity associated with these symptoms, and perform recordings of the surface of the brain, in addition to the typical recordings the investigators perform, during routine deep brain stimulation (DBS) surgery.

What's being tested

  • Procedure/Surgery: Response Inhibition and Deep Brain Stimulation in Parkinson's disease

    Intervention · OTHER

    After creation of the burr hole and prior to DBS electrode placement, 1-2 subdural strip electrodes will be placed anteriorly or posteriorly from the cranial opening. These electrodes are routinely placed using this technique for seizure mapping, with arrays of electrodes (up to 6) being placed around the perimeter of the opening.14 Subdural strips vary in length and contact size (e.g., the 6-contact Ad-Tech strip), and are currently placed predominantly for studies of sensorimotor function,13 including at our institution (IRB-140327003). Placement over prefrontal areas is performed at other institutions.11-13 The DBS surgery will then proceed according to routine practice, and following lead placement in the optimal desired location, the research task paradigm will begin.

Study details

Sponsor
University of Alabama at Birmingham
Conditions
Parkinson Disease
Enrolling
140 people
Starts
2021-04-01
Est. completion
2028-03-31
Design
Single-blind, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗