What this study is
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
What's being tested
- Nicotine gum
Intervention · OTHER
Nicotine (6 mg) will be administered in the form of polacrilex gum that is available as an over-the-counter medication
- Placebo gum
Intervention · OTHER
The placebo will also be a commercially available gum that resembles the nicotine gum in flavor, size, shape, color, and texture.
Study details
- Official title
- Using Nicotine to Reverse Age-related Auditory Processing Deficits: Human Psychophysics and Electrophysiology
- Sponsor
- University of California, Irvine
- Conditions
- Auditory Perceptual Impairment · Aging
- Enrolling
- 48 people
- Starts
- 2022-02-01
- Est. completion
- 2026-12-31
- Design
- Double-blind, randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 85 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- Between 18 and 85 years of age
- Non-smokers with a score of 0-2 out of 10 maximum on the Fagerström index of smoking dependency
- Cognitive performance within two standard deviations of the CERAD mean
You can't join if
- Less than 18 or greater than 85 years of age
- Deafness or excessive hearing loss
- Smokers with a score between 3 and 10 on the Fagerström index of smoking dependency
- History of psychiatric illness, neurological disorders, diabetes mellitus, renal failure, or cardiovascular disease
- Regular use of prescription medications (excluding oral contraceptives)
- Drug dependency
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openHearing and Speech Lab
Irvine, California, United States
- Fan-Gang Zeng · Contact9498249107fzeng@uci.edu
RecruitingSan Diego State University
San Diego, California, United States
- Xianhui (Kaye) Wang, PhD · Contact619-594-7746kwang5@sdsu.edu
Recruiting
Study team
Sponsor
University of California, Irvine
Study ID 20139964
Principal investigator
Fan-Gang Zeng, PhD
University of California, Irvine
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.