What this study is
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device. By combining behavioral tasks with neural recordings, the study seeks to uncover how DBS affects motivation, particularly in relation to effort, reward, and timing.
What's being tested
- Stimulation on
Intervention · OTHER
Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.
- Stimulation off
Intervention · OTHER
Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.
- Decision Making Task
Intervention · BEHAVIORAL
Patients will be playing a decision making task through a computer-based application.
Study details
- Sponsor
- University of California, San Francisco
- Conditions
- Parkinson Disease · Deep Brain Stimulation · Motivation
- Enrolling
- 70 people
- Starts
- 2021-10-30
- Est. completion
- 2030-12-01
- Design
- Open-label, non-randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Has Parkinson's Disease or Dystonia
- Has Medtronic Percept or RC+S DBS device implanted in either GPI or STN
- Has DBS device implanted either bilaterally or unilaterally
- Male or female
- More than 1 month post-DBS surgery
You can't join if
- Severe cognitive impairments
- Has MOCA score below 20
- Pregnancy
- Age less than 18 years old
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of California San Francisco
San Francisco, California, United States
- Sarah Wang, PhD · Contact415-353-7885Sarah.Wang@ucsf.edu
- Simon J Little, MBBS, PhD · Principal investigator
Recruiting
Study team
Sponsor
University of California, San Francisco
Study ID 20-31239
Principal investigator
Simon J Little, MBBS, PhD
University of California, San Francisco
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.