Skip to main content
HealthySupplementsNutrition and dietMicrobiomeHealthy volunteersHealthmaxxingDrugDietary supplement

What this study is

The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.

What's being tested

  • Omeprazole

    Intervention · DRUG

    40 MG oral capsules daily

  • Lactobacillus rhamnosus GG

    Intervention · DIETARY SUPPLEMENT

    Given as Culturelle Digestive Probiotic in the form of oral capsules daily

  • Placebo

    Intervention · DRUG

    Oral capsules daily that look exactly like the study drug, but contains to active ingredient

Study details

Official title
Exploratory Study of the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis
Sponsor
Mayo Clinic
Conditions
Healthy
Enrolling
30 people
Starts
2023-03-03
Est. completion
2026-12
Design
Double-blind, randomized, parallel groups
Record
View on ClinicalTrials.gov ↗