What this study is
Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.
What's being tested
- Intermittent Theta Burst Stimulation (iTBS)
Intervention · DEVICE
iTBS is a form of non-invasive brain stimulation used to treat depression. It works on the principles of electromagnetic induction.
Study details
- Official title
- Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric Diseases
- Sponsor
- Massachusetts General Hospital
- Conditions
- Major Depressive Disorder
- Enrolling
- 80 people
- Starts
- 2024-03-12
- Est. completion
- 2029-05-31
- Design
- Double-blind, non-randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 65 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- 18-65 years of age
- Capacity to provide informed consent form to participate in the study Inclusion Criteria for participants with Major Depressive Disorder (MDD):; 18-65 years of age; Capacity to provide informed consent form to participate in the study; Currently in a major depressive episode. Comorbid anxiety disorders and personality disorders will be allowed provided that MDD is the primary diagnosis.
You can't join if
- Meeting criteria, in the past or currently, for bipolar affective disorder, hypomania or mania.
- Meeting criteria, in the past or currently, for a primary psychotic disorder (e.g., schizophrenia).
- Neurological conditions with known structural brain lesions, e.g., intracranial masses, multiple sclerosis.
- Any personal history of seizures or a family history of epilepsy in a first-degree relative.
- Metal in the body that is ferromagnetic or metallic injury to the eyes.
- Implanted pacemakers, medication pumps, vagal stimulators, deep brain stimulators, or ventriculoperitoneal shunts, etc.
- Substance abuse or dependence that is current and active within the last six months, as indicated by self-report (e.g., heroin, cocaine, methamphetamines).
- Inability to meet the safety criteria for MRI scanning for any other reason.
- Severe or unstable medical illness.
- Currently pregnant, as assessed with urine pregnancy test in women of childbearing age.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openMassachusetts General Hospital
Boston, Massachusetts, United States
- Mark Eldaief, MD · Contact617-726-1728meldaief@partners.org
Recruiting
Study team
Sponsor
Massachusetts General Hospital
Study ID 2022P002110
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.