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Major Depressive DisorderCognitive functionMental healthBehavioralHealthy volunteersDevice

What this study is

Repetitive transcranial magnetic stimulation (rTMS) is a way of non-invasively stimulating specific brain networks and is an established treatment for Major Depressive Disorder (MDD). This proposal will reveal network mechanisms of the therapeutic effects of rTMS by investigating how stimulating each network specifically changes network connectivity and behavior. This will be done in a highly individualized manner in depressed and healthy patients, leading to more effective and more individualized treatments for depression.

What's being tested

  • Intermittent Theta Burst Stimulation (iTBS)

    Intervention · DEVICE

    iTBS is a form of non-invasive brain stimulation used to treat depression. It works on the principles of electromagnetic induction.

Study details

Official title
Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric Diseases
Sponsor
Massachusetts General Hospital
Conditions
Major Depressive Disorder
Enrolling
80 people
Starts
2024-03-12
Est. completion
2029-05-31
Design
Double-blind, non-randomized, crossover
Record
View on ClinicalTrials.gov ↗