What this study is
Background:
More than 6.5 million people in the United States live with heart failure (HF), and more than a million new cases are diagnosed each year. Treatments have improved in recent years, but researchers want to understand more about how HF develops. To do this, they need to compare blood and other samples from many people with HF.
Objective:
To collect blood and other samples from people with HF. These samples will be used to identify and study proteins and other factors that may lead to decreased heart function over time.
Eligibility:
People aged 18 years and older with heart failure.
Design:
Participants will be asked to join the study based on a review of their medical records.
They will have 1 study visit. They will provide a blood sample: About 3 tablespoons will be collected from a needle inserted into a vein.
Other tests are optional: Participants may provide urine and stool samples. They may have a cotton swab rubbed on the inside of the mouth to collect DNA.
Participants may also take 3 questionnaires. They will answer questions about dietary, social, and other factors that affect their health. Participants will receive compensation.
Researchers will follow the participants health by monitoring their medical records for up to 5 years.
Study details
- Official title
- Multi-scale Phenotyping of Heart Failure: From Precision Phenotyping to Population Inference (PHENO-HEART)
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
- Conditions
- Heart Failure
- Enrolling
- 2,000 people
- Starts
- 2026-11-11
- Est. completion
- 2034-04-30
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 100 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Clinical diagnosis of "active" HF documented by a cardiology provider's note in the medical record. Active HF is the presence of signs or symptoms that are deemed to be related to heart failure, as documented in the participants' medical records.
- Able and willing to undergo the consent process and provide consent
- Willing to comply with required study activities
- 18 years of age or older
You can't join if
- History of ventricular assist device
- History of cardiac transplant
- Living or residing outside of the geographic location designated for the study at the time of enrollment
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openUniversity of Maryland School of Medicine
Baltimore, Maryland, United States
INOVA Fairfax Hospital
Falls Church, Virginia, United States
Study team
Sponsor
National Heart, Lung, and Blood Institute (NHLBI)
Study ID 10001889
Principal investigator
Veronique L Roger, M.D.
National Heart, Lung, and Blood Institute (NHLBI)
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.