Comparing intracardiac and transesophageal echocardiography for guiding left atrial appendage closure

You may qualify if

• Patients diagnosed for non-valvular atrial fibrillation with documented paroxysmal, persistent, or permanent NVAF.
• Deemed to be at high risk of stroke or systemic embolism (SE) defined as a CHADS2 score ≥2 or a CHA2DS2-VASc score ≥3.
• Patient suitable for OAC with warfarin or DOAC and have appropriate rationale to seek a nonpharmacologic alternative to long-term OAC, meeting commercial LAAO criteria indications.
• Can undergo appropriate pre-procedural imaging with Computed tomography (CT) or transesophageal echocardiography (TEE).
• Patient should be able to comply with the protocol.
• Provide written informed consent before study participation.
• Ages 18 and above

You can't join if

• Presence of an intracardiac thrombus on the preprocedural TEE or CT.
• History of previously implanted device for atrial septal defect or patent foramen ovale.
• Severe LV dysfunction (LVEF < 40%) or greater than moderate valvular heart disease.
• Enrollment in another study that competes or interferes with this study. Approval to dual enroll must be approved by the other study.
• Poor clinical condition like cardiogenic shock, which prohibits pre- and post-procedural function tests.
• Subject with planned cardiac intervention between the time of consenting and up to 60 days post-LAAO.
• Any other condition or co-morbidity which, in the opinion of the investigator or operator, may pose a significant hazard to the subject if he or she is enrolled in the study.
• For women of childbearing potential: Pregnant or breastfeeding women or planning pregnancy during the course of the investigation are excluded due to the risks involved in the procedure
• Children below 18 years, prisoners and patients who are unable to provide consent are excluded.