What this study is
The goal of this research study is to learn how the brain areas that plan and control movement interact with the areas responsible for hearing and perceiving speech in healthy adults and people who have had cerebellar strokes. The main questions it aims to answer are:
1. What regions of the brain's sensory systems show changes in their activity related to speech? 2. To what extent do these regions help listeners detect and correct speech errors? 3. What is the role of the cerebellum (a part of the brain in the back of the head) in these activities?
Participants will be asked to complete several experimental sessions involving behavioral speech and related tests and non-invasive brain imaging using electroencephalography (EEG) and functional magnetic resonance imaging (fMRI).
What's being tested
- Neural responses to speech functional localizer
Intervention · BEHAVIORAL
Measuring speech-related brain activity using fMRI during a speech listening task.
- Neural responses to silent articulation
Intervention · BEHAVIORAL
Measuring speech-related brain activity using fMRI during a silent articulation task.
- Neural responses to self vs. externally generated speech
Intervention · BEHAVIORAL
Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.
- Event-related potentials for speech
Intervention · BEHAVIORAL
Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech
- Neural responses to induced speech errors
Intervention · BEHAVIORAL
Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.
- Neural responses to sensory-motor adaptation
Intervention · BEHAVIORAL
Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.
- Speech production behaviors
Intervention · BEHAVIORAL
Behavioral measurements of speech during reading passages and words
- Auditory acuity testing
Intervention · BEHAVIORAL
Measurements of auditory acuity during listening tasks.
- Neural responses to learning a non-speech auditory motor behavior
Intervention · BEHAVIORAL
Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Study details
- Official title
- High-resolution Functional Imaging of Speech-induced Sensory Modulation
- Sponsor
- University of Pittsburgh
- Conditions
- Stroke · Cerebellum
- Enrolling
- 100 people
- Starts
- 2025-05-27
- Est. completion
- 2028-07
- Design
- Open-label, single group
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers AcceptedCohort 1
You may qualify if
- Age 18-49
- Right-handed
- Native English speaker
You can't join if
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Hearing loss, defined by pure tone thresholds >25 decibels (dB) hearing level (HL) at octave frequencies between 250-8000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
Cohort 2
You may qualify if
- Age 18 or older
- Right-handed
- Native English speaker
- History of cerebellar stroke
You can't join if
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury other than stroke
- Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
Cohort 3
You may qualify if
- Age 18 or older
- Right-handed
- Native English speaker
You can't join if
- Presence of MRI risk factors: metal and/or electromagnetic devices (e.g., pacemakers, neurostimulators) in the body, previous shrapnel injuries, use of an intrauterine device containing metal, claustrophobia, pregnant or possibly pregnant
- History of neurological / neurodegenerative disease or severe brain injury (e.g., stroke or severe traumatic brain injury)
- Hearing loss, defined by pure tone thresholds >50 dB HL at octave frequencies between 250-4000 Hz
- Clinical diagnosis and/or treatment for schizophrenia or other psychotic disorders
- Clinical diagnosis and/or treatment for neurocognitive disorders (e.g., dementia, delirium)
- Presence of a severe and unmanaged, clinically diagnosed attention disorder
- Clinically diagnosed with or treated for a speech, language, or hearing disorder
- Head circumference greater than 60cm or weight greater than 300 pounds
- History of severe claustrophobia
- Currently pregnant
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of Pittsburgh
Pittsburgh, Pennsylvania, United States
- Jason Bohland, Ph.D. · Contact412-383-3416j.bohland@pitt.edu
- Alexander Ocampo, BA · Contactamo104@pitt.edu
- Jason W Bohland, Ph.D. · Principal investigator
Recruiting
Study team
Sponsor
University of Pittsburgh
Study ID STUDY23070083
Principal investigator
Jason W Bohland, Ph.D.
University of Pittsburgh
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.