What this study is
The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.
What's being tested
- continuous theta-burst stimulation (cTBS)
Intervention · DEVICE
cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.
- Adaptation
Intervention · BEHAVIORAL
Auditory adaptation in speech
- Single pulse Transcranial magnetic stimulation (TMS)
Intervention · DEVICE
TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.
- fMRI
Intervention · DEVICE
To assess functional connectivity patterns between regions that predict learning.
Study details
- Official title
- Sensorimotor Basis of Speech Motor Learning and Retention
- Sponsor
- Yale University
- Conditions
- Speech
- Enrolling
- 330 people
- Starts
- 2024-10-01
- Est. completion
- 2029-05-31
- Design
- Open-label, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 40 YearsSex ALLHealthy volunteers AcceptedYou may qualify if
- Fluent English speakers
- Right-handed
- Normal hearing
- No speech disorder or reading disability
You can't join if
- Cardiac pacemaker
- Aneurysm clip
- Heart or Vascular clip
- Prosthetic valve
- Metal implants
- Metal in brain, skull, or spinal cord
- Implanted neurostimulator
- Medication infusion device
- Cochlear implant or tinnitus (ringing in ears)
- Personal and/or family history of epilepsy or other neurological disorders or history of head concussion
- Psychoactive medications
- Pregnancy
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openYale Child Study Center
New Haven, Connecticut, United States
Recruiting
Study team
Sponsor
Yale University
Study ID 2000037622
Principal investigator
David Ostry
Yale University
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.