Alcohol Use DisorderAddictionMental healthBehavioralDevice
What this study is
This study aims to examine the effects of Low-Intensity Focused Ultrasound (LIFU) on brain activity in patients with alcohol use disorder.
What's being tested
- Low Intensity Focused Ultrasound
Intervention · DEVICE
An inhibitory LIFU protocol that allows suppression of neuronal activity in the basal ganglia and thalamus will be used.
Study details
- Sponsor
- University of California, San Francisco
- Conditions
- Alcohol Use Disorder
- Enrolling
- 25 people
- Starts
- 2025-01-07
- Est. completion
- 2030-09
- Design
- Double-blind, randomized, crossover
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years and overSex ALLHealthy volunteers Not acceptedYou may qualify if
- Male or female ≥ 18 years of age.
- Documentation of an AUD diagnosis per DSM-5 criteria as evidenced by problematic pattern of alcohol use leading to clinically significant impairment or distress, as manifested by at least two of the DSM-5 criteria, occurring within a 12-month period.
- Be willing to undergo a brain MRI and follow study protocol.
You can't join if
- Pregnant or breastfeeding.
- Presence of a condition or abnormality that would compromise the safety of the patient or the quality of the data.
- Non-English speaking.
- Other investigational AUD treatments.
- Primary psychosis, Bipolar I, or severe personality disorder.
- Active suicidality or history of suicide attempt in the past 5 years.
- Cognitive impairment (MoCA <24)
- Significant medical or neurological disease, or life expectancy <12 mos.
- Significant brain abnormality on brain imaging.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (1)
1 openUniversity of California, San Francisco
San Francisco, California, United States
- Catherine Borror, BS, CCRP · Contact415-514-6551TN2Lab@ucsf.edu
- Sierra Brandts, BS · Contact415-514-6551TN2Lab@ucsf.edu
- Khaled Moussawi, MD, PhD · Principal investigator
- Andrew Kayser, MD, PhD · Sub-investigator
Recruiting
Study team
Sponsor
University of California, San Francisco
Study ID 24-41883
Principal investigator
Khaled Moussawi, MD, PhD
University of California, San Francisco
Have questions? The contacts above can answer them before you apply.
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.