What this study is
Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.
What's being tested
- Music video game
Intervention · BEHAVIORAL
The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'
Study details
- Sponsor
- University of Maryland, Baltimore
- Conditions
- Schizophrenia Disorders
- Enrolling
- 36 people
- Starts
- 2025-01-02
- Est. completion
- 2026-12-31
- Design
- Single-blind, randomized, parallel groups
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 15 Years – 45 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- Diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or psychosis NOS
- Age 15-45
- Able to provide informed consent
You can't join if
- Contraindications to MRI (metal implants, claustrophobia)
- Medical condition that limits use of hands (ie, arthritis)
- Active or recent (within 6 months) substance use disorder other than nicotine
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (2)
2 openMaryland Psychiatric Research Center
Catonsville, Maryland, United States
- Joshua Chiappelli, MD · Contact410-402-6827jchiappe@som.umaryland.edu
RecruitingUniversity of Maryland Baltimore - Maryland Psychiatric Research Center
Catonsville, Maryland, United States
- Joshua J Chiappelli, MD · Contact410-402-6827jchiappe@som.umaryland.edu
Not yet recruiting
Study team
Sponsor
University of Maryland, Baltimore
Study ID HP-00081020
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.