What this study is
The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.
What's being tested
- MZE829
Intervention · DRUG
Capsules for oral administration
Study details
- Official title
- An Open-Label Phase 2 Study to Evaluate the Safety, Tolerability, and Effect on Albuminuria of MZE829 in Adults With Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype
- Sponsor
- Maze Therapeutics
- Conditions
- Proteinuric Kidney Disease
- Enrolling
- 74 people
- Starts
- 2025-02-05
- Est. completion
- 2026-09
- Design
- Open-label, single group, Phase 2
- Record
- View on ClinicalTrials.gov ↗
Who can join
Age 18 Years – 68 YearsSex ALLHealthy volunteers Not acceptedYou may qualify if
- APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2
- Chronic kidney disease with persistent albuminuria
You can't join if
- Organ or bone marrow transplantation
- History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer
- Conditions that may alter drug absorption, e.g., history of bariatric surgery
- Type I diabetes
- Pregnant or currently nursing Other inclusion/exclusion criteria defined in protocol apply.
Sign in and we'll check these against your records.Full criteria on ClinicalTrials.gov ↗
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Study locations (79)
79 openResearch Site
Decatur, Alabama, United States
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Huntsville, Alabama, United States
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Montgomery, Alabama, United States
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Montgomery, Alabama, United States
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Bloomfield, Connecticut, United States
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Washington D.C., District of Columbia, United States
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Atlantis, Florida, United States
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Brandon, Florida, United States
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Hollywood, Florida, United States
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Melbourne, Florida, United States
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Orlando, Florida, United States
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Atlanta, Georgia, United States
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College Park, Georgia, United States
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Cordele, Georgia, United States
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Macon, Georgia, United States
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Riverdale, Georgia, United States
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Riverdale, Georgia, United States
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Savannah, Georgia, United States
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Snellville, Georgia, United States
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Chicago, Illinois, United States
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Chicago, Illinois, United States
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Evanston, Illinois, United States
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Kansas City, Kansas, United States
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Bowling Green, Kentucky, United States
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Louisville, Kentucky, United States
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Arnold, Maryland, United States
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Lutherville, Maryland, United States
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Oxon Hill, Maryland, United States
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Dearborn, Michigan, United States
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Flint, Michigan, United States
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Pontiac, Michigan, United States
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Saint Joseph, Michigan, United States
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Minneapolis, Minnesota, United States
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Tupelo, Mississippi, United States
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City of Saint Peters, Missouri, United States
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St Louis, Missouri, United States
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Las Vegas, Nevada, United States
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Jersey City, New Jersey, United States
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Buffalo, New York, United States
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Laurelton, New York, United States
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Maspeth, New York, United States
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Newburgh, New York, United States
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Durham, North Carolina, United States
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Fayetteville, North Carolina, United States
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Greensboro, North Carolina, United States
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Shelby, North Carolina, United States
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Cleveland, Ohio, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Ardmore, Oklahoma, United States
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Philadelphia, Pennsylvania, United States
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Philadelphia, Pennsylvania, United States
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Upland, Pennsylvania, United States
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Columbia, South Carolina, United States
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Spartanburg, South Carolina, United States
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Spartanburg, South Carolina, United States
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Chattanooga, Tennessee, United States
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Dallas, Texas, United States
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Dallas, Texas, United States
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Greenville, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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McKinney, Texas, United States
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San Antonio, Texas, United States
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Shenandoah, Texas, United States
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Sherman, Texas, United States
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Norfolk, Virginia, United States
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11 sites outside the US
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Créteil, France
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Lille, France
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Lyon, France
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Paris, France
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Paris, France
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Paris, France
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Saint-Ouen, France
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Leicester, United Kingdom
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London, United Kingdom
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London, United Kingdom
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London, United Kingdom
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Study team
Sponsor
Maze Therapeutics
Study ID MZE829-201
Study director
Medical Director
Maze Therapeutics
Frequently asked questions
The sponsor hasn't published answers to common questions for this trial.