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Laceration of SkinSkinDrugPhase 3

What this study is

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

What's being tested

  • Lidocaine

    Intervention · DRUG

    Lidocaine local infiltration

  • Diphenhydramine

    Intervention · DRUG

    Diphenhydramine local infiltration

Study details

Sponsor
Florida Atlantic University
Conditions
Laceration of Skin
Enrolling
100 people
Starts
2025-09-03
Est. completion
2028-06-30
Design
Double-blind, randomized, parallel groups, Phase 3
Record
View on ClinicalTrials.gov ↗